Positions, News, & Upcoming Events
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Faculty Research Lecture by CEPCEB Director Natasha Raikhel: May 16, 2008 |
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24th Symposium in Plant Biology — "Gene Silencing: The Biology of Small RNAs and the Epigenome" — January 18-20, 2007 at the Riverside Convention Center
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CEPCEB Seminars |
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Bioinformatics Workshops and Related Seminars |
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Microscopy Workshops |
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Genomics Building Ceremonial Groundbreaking: October 18, 2006 |
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2008 CEPCEB NSF Research Experiences for Undergraduates (REU) Program |
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ChemGen IGERT Associate Director Sean Cutler Discusses Chemical Genomics on ReachMD Radio XM157 |
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Faculty Research Lecture by CEPCEB Director Natasha Raikhel: May 16, 2008 |
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2008 High School Recipient of CEPCEB Plant Cell Biology 1st Place Awards at both the California State Fair and RIMS Inland Science & Engineering Fair |
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Outstanding 2008 CEPCEB Postdoctoral, Graduate Student and Undergraduate Student Awards Recognized at Sixth Annual CEPCEB Award Ceremony: January 18, 2008 |
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CEPCEB/IIGB Member Xinping Cui Recipient of NSF Database and Informatics Grant |
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CEPCEB/IIGB Member Sean Cutler's Publication in Nature Chemical Biology Explores Drug Resistance in Humans |
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CEPCEB Member Venugopala Reddy Gonehal Awarded $1M by NSF to Study Plant Stem Cell Identify Factors |
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CEPCEB Member Hailing Jin Recipient of NSF Career Award |
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2007 Recipients of CEPCEB Plant Cell Biology Awards at the California State Science Fair |
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2007 Recipients of the CEPCEB Plant Cell Biology Awards at the RIMS Inland Science & Engineering Fair Winners |
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CEPCEB Director Natasha Raikhel Recipient of the 2007 Fellow of ASPB Award |
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CEPCEB IGERT Graduate Student Colleen Knoth Receives 8th Annual W.W. Thomson Award for Outstanding Research |
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CEPCEB Member Cynthia Larive Receives the 2007 J. Calvin Giddings Award for Excellence in Education
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CEPCEB Member Xuemei Chen and IIGB Member Cheryl Hayashi Appointed 2006-07 University Scholars! |
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Congratulations to 2007 Recipients of Outstanding CEPCEB Postdoctoral, Graduate Student and Undergraduate Student Awards at Fifth Annual CEPCEB Award Ceremony:February 9, 2007 |
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CEPCEB Student Michelle Brown Recipient of Chancellor's Distinguished Fellowship |
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CEPCEB Member Xuemei Chen Recipient of 2006 Charles Albert Shull Award |
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August 2006 Nature and The Plant Cell Papers by CEPCEB Member Julia Bailey-Serres Offers Hope of Submergence Tolerant Rice Lines for Poor Rice Farmers |
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High-throughput Genomics Paper Published in June 2006 PNAS Issue by CEPCEB Member Katherine Borkovich |
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CEPCEB Site for 2007 NSF Research Experience for Undergraduates (REU) Program |
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CEPCEB Member Thomas Eulgem Receives 2006 Chancellor's Award for Excellence in Undergraduate Research |
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March 2006 Article in Science by CEPCEB Member Shou-wei Ding and Colleagues Show Fruit Flies Employ Same Defense Mechanism Against Viruses as Plants |
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CEPCEB Member Stefano Lonardi Part of $5 Million USDA Research Consortium to Produce Better Barley |
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CEPCEB Member Mihri Ozkan Receives Distinguished Engineering Educator Award |
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researcher Shou-Wei Ding and UCR Researchers
Discover Model Organism (C. elegans) for Studying Host-virus Interactions | |  | CEPCEB
Researchers Earn First NSF IGERT Grant for UCR ($2.9 Million) | |  | Congratulations
to Thomas Girke as Recipient of the 2004-05
UCR Non-Senate Distinguished Research-Instruction Award | |
 | ChemMine:
Compound Mining Database Developed by CEPCEB Member Thomas
Girke Open to Public | |
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Member Stefano Lonardi Awarded Five-Year NSF
CAREER Grant Involving Bioinformatics Research | |
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Member Zhenbiao Yang's Paper in Cell
(March 11, 2005) Explains Jigsaw-like Pattern of Plant Cells Contributing to Leaf
Strength | |
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of CEPCEB REU Students to Published Works | |  | CEPCEB
Member Mihri Ozkan Recipient of Visionary
Science Award by ISBBN | |  | Natasha
Raikhel Recipient of 2004 Stephen Hales Prize | |  | CEPCEB
Member Katherine Borkovich First Author in
MMBR Article that Analyzes over 1,100 genes of fungus Neurospora crassa (March
2004) | |  | CEPCEB
Member Elizabeth Lord's PNAS Paper (December
2003) Identifies Plant Reproduction Protein | |  | CEPCEB
Small Research Grants Awarded for Microscopy and Imaging | |
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Published in the Proceedings of the National Academy of Sciences (PNAS) June 10,
2003 issue by Raikhel
Lab | |  | June
2003 Issue of Plant Physiology Has Significant CEPCEB Achievements | |
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Member Katherine Borkovich's Paper
Published in Nature Involving Sequencing of the Neurospora Genome
(April 24, 2003) | |  | CEPCEB
Paper (Zhenbiao Yang, Ying Fu) Selected as
Fast Breaking by ISI Essential Science Indicators | |
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Research Funded by U.S. Department of Energy (featuring CEPCEB Member Zhenbiao
Yang's Research) | |
 | Natasha
Raikhel: Recipient of ASCB Women in Cell Biology Senior Career Recognition
Award | |  | CEPCEB
Member Shou-Wei Ding's Paper Published in
Science (May 2002) | |
 | Collaborative
Work of Three CEPCEB Members Published in Science (June 2002) | |
 | CEPCEB
Member Julia Bailey-Serres:
2002 Chancellor's Award for Outstanding Faculty Mentor | |
 | Natasha
Raikhel: One of Most Highly Cited Researchers | |
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ChemGen IGERT Associate Director Sean Cutler Discusses Chemical Genomics on ReachMD Radio XM157
On a segment titled "The Fruit Fly of Plants -- Testing Drugs on Plants" on ReachMD Radio XM157, ChemGen IGERT Associate Director and Plant Cell Biologist Sean Cutler discusses how scientists can learn about drugs and their side effects on humans by studying their impact on the model plant, Arabidopsis thaliana. As part of the "Innovations in Medicine" series hosted by Paul Raeburn and directed at medical professionals, Dr. Cutler talks about the benefits of studying Arabidopsis thaliana due to its common occurrence, small genome properties, simple and fast growth cycle, and low cost. Listen to Dr. Cutler discuss how chemicals are being used on Arabidopsis to identify new genes responsible for controlling "pharmocogenetic variation," or the variable human responses elicited from drugs, and how his lab is using this knowledge to control the growth and development of organisms and further our understanding of how complex organisms work.
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Faculty Research Lecture by CEPCEB Director Natasha Raikhel: May 16, 2008
The honor of Faculty Research Lecturer for the 2007-08 academic year was bestowed upon Natasha Raikhel by the UCR Academic Senate Committee. This award recognizes superior achievement in research and is presented annually by the Chancellor to only one campus individual. According to Thomas Cogswell, Chair of the Academic Senate:
The Faculty Research Lecturer Committee is honored to place in nomination Natasha Raikhel, Distinguished Professor of Botany and Plant Sciences, a scholar who, by every standard we could think of, will add luster to the award. Professor Raikhel’s studies of the molecular mechanisms governing trafficking in plants and of genetic control of cell wall polysaccharide biosynthesis have made lasting scientific contributions in plant biology. She has pioneered the use of chemical genomics to advance our knowledge of plant processes. Director of the Center for Plant Cell Biology, Professor Raikhel has pushed back the frontiers of the field, with what her colleagues describe as her “superb experimentalist,” if not “traditionalist,” approach: “It is fair to say that she is the world expert in this area” of “secretory trafficking,” especially with regard to its “multiple functions.”
To celebrate this honor, Dr. Raikhel will present a talk titled "Plant Biology: From Cells to Systems?" on May 16, 2008 at 3:30pm in the University Theatre. There will be a reception at 5:00pm following the lecture at the Chancellor's residence. |
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2008 High-School Recipient of CEPCEB Plant Cell Biology 1st Place Awards at both the California State Fair and RIMS Inland Science & Engineering Fair
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SRAVYA KEREMANE
John W. North High School
Poster Title:
"Biochemical Analysis of the Mechanisms of Cold Tolerance in Citrus"
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2008 California State Fair and
2008 RIMS Inland Science and Engineering Fair
CEPCEB Plant Cell Biology FIRST PLACE AWARDS |
Sravya Ramadugu Keremane, a senior from John W. North High School in Riverside, received the UCR Center for Plant Cell Biology (CEPCEB) First Place Plant Cell Biology Award at both the regional and statewide 2008 science fairs! In 2002, CEPCEB initiated the CEPCEB Award Fund to recognize research excellence in plant cell biology, genomics and bioinformatics by pre-college students, graduate students, and postdoctoral researchers. CEPCEB researchers Marcela Pierce and Eun-Ju Sohn from the Botany & Plant Sciences department attended and evaluated presentations at the California State Science Fair held on May 20, 2008 and presented Ms. Keremane a cash prize ($1000) for her poster titled "Biochemical Analysis of the Mechanisms of Cold Tolerance in Citrus."
Previously, Ms Keremane received CEPCEB's first place award on April 16, 2008 at the Inland Science and Engineering Fair in San Bernardino, California for the same poster. The Inland Fair is an annual competition of science projects designed, developed, and displayed by elementary and secondary students from schools in Riverside, Inyo, Mono and San Bernardino (RIMS) counties. CEPCEB annually acknowledges scientific achievement at this fair in the fields of cell and molecular biology, genomics, bioinformatics, or technology development by a student in grades 9-12. The recipient of this award receives $100, a CEPCEB Award Certificate, and is invited to participate in the annual CEPCEB Noel T. Keen Lecture and Award Ceremony. CEPCEB appreciates the contribution of Harley Smith for participating as a judge in this event, and the many who have donated to this fund in support of a new cohort of talented young scientists in our community.
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Outstanding CEPCEB Postdoctoral, Graduate Student and Undergraduate Student Awards Recognized at Sixth Annual CEPCEB Award Ceremony: January 18, 2008
The following individuals were recognized for their outstanding scientific achievements during 2007-08:
Outstanding CEPCEB
Postdoctoral Fellow(s) |
Outstanding CEPCEB
Postdoctoral Fellow(s) |
Outstanding CEPCEB Graduate
Student |
Outstanding CEPCEB Undergraduate
Student |
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EUN-JU (JULIE) SOHN
Botany & Plant Sciences
(Mentor:N. Raikhel)
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MARCELA ROJAS-PIERCE
Botany & Plant Sciences
(Mentor: N. Raikhel) |
COLLEEN KNOTH
Botany & Plant Sciences
(Mentor: T. Eulgem) |
ZUH JYH (DANIEL) LIN
Botany & Plant Sciences
Mentor: V. G. Reddy |
The sixth annual CEPCEB Special Award Ceremony was held January 18, 2008 from 2-4pm in the Science Library, Room 240. These CEPCEB awards annually recognize research excellence in plant cell biology, genomics, bioinformatics and bioengineering by pre-college students, undergraduate students, graduate students, and postdoctoral researchers. The Award Fund also sponsors an annual special seminar and awards ceremony where an invited prominent scientist presents his or her work.The CEPCEB Awards have a monetary value of $500 each, and awardees' names are added to a permanent plaque.
CEPCEB would like to congratulate the individuals above for their well-deserved awards!
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Gloria M. Coruzzi
Carroll and Milton Petrie Professor
Chair, Department of Biology
New York University |
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Sixth Annual Noel T. Keen Lecturer:
Dr. Gloria Coruzzi, a Carroll and Milton Petrie Professor and Chair of the Department of Biology at New York University, was the annual Noel T. Keen Lecturer at the sixth annual Award Ceremony. Dr. Coruzzi has been a professor at New York University (NYU) for the past 16 years and currently serves as Chair of the Biology Department. Prior to her professorship at NYU, she was a faculty member at Rockefeller University since 1983, and has published over 90 papers in major journals. Her prominent stature and groundbreaking discoveries in the scientific field have allowed her to currently be awarded over $20 million of federal funding for research projects.
The research in Dr. Coruzzi’s lab is focused on identifying the underlying mechanisms responsible for the transcriptional regulation of metabolic networks in Arabidopsis. In particular, her studies involve identifying gene networks, whose expression is controlled by the intersection of light, carbon and nitrogen signals, and the regulatory pathways controlling them.
Title of Dr. Coruzzi's talk: A Systems Approach to Nitrogen Regulatory Networks and the Virtual Plant.
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CEPCEB/IIGB Member Xinping Cui Recipient of NSF Database and Informatics Grant
IIGB/Cepceb Member and Assistant Professor of Statistics Xinping Cui was awarded a three-year NSF grant from the Database and Informatics Program for her project titled "Statistical and Computation Tools for Identifying Microarray-based Expression and Single Feature Polymorphism Markers in Crops." This project aims to develop a new unified statistical protocol and software to integrate the use of microarray expression data, sequence data and functional genomics for the detection of genetic polymorphisms (SFPs and GEMs) on large-genome species. Congratulations to Dr. Cui in this highly competitive award!
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CEPCEB/IIGB Member Sean Cutler's Publication in Nature Chemical Biology Explores Drug Resistance in Humans
In the Sept. 23, 2007 online publication of Nature Chemical Biology, IIGB/CEPCEB Member and Plant Cell Biologist Sean Cutler and his lab discovered a key protein in the model plant Arabidopsis thaliana that creates drug resistance. By analyzing the effect of biochemical processes on simple organisms such as plants, the Cutler lab was able to explore factors influencing variations in drug responses and drug sensitivities in humans. UCR Press Release [dated September 26, 2007] |
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CEPCEB Member Venogopala Reddy Gonehal Awarded $1M by NSF to Study Plant Stem Cell Identify Factors
IIGB and CEPCEB Member Venugopala Reddy Gonehal was recently awarded $1M by the National Science Foundation to study factors related to plant stem cell identity, maintenance, and transition to different cell types. Dr. Reddy and the UCR postdoctoral fellows and graduate students in his lab will isolate stem cells in the model plant Arabidopsis and attempt to decipher gene identify and function over the four-year project period. By utilizing microgenomics and live imaging techniques, Dr. Reddy hopes to gain further insight into stem cell regulation and communication. UCR Press Release [dated September 6, 2007]
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CEPCEB Member Hailing Jin Recipient of NSF CAREER Award
CEPCEB Member Hailing Jin has been awarded a five-year NSF CAREER award in the amount of $745,000 for her project titled ""CAREER:Genome-wide Analysis of Pathogen-induced Endogenous siRNAs in Plant Defense Responses in Arabidopsis." This project proposes to reveal new regulatory mechanisms underlying plant disease resistance and defense responses and ultimately contribute to the development of new strategies to combat plant pathogens to improve agriculture.
The Faculty Early Career Development (CAREER) Program is a Foundation-wide activity that offers the National Science Foundation's most prestigious awards in support of the early career-development activities of those teacher-scholars who most effectively integrate research and education within the context of the mission of their organization. Congratulations to Hailing Jin on this distinguished achievement!
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2007 Recipients of CEPCEB Plant Cell Biology Awards at the California State Science Fair
The CEPCEB Plant Cell Biology Award acknowledges scientific achievement in the fields of cell and molecular biology, genomics, bioinformatics, or technology development. While research in these areas using plant systems is an advantage, other model systems are considered if there is relevance to the field of plant biology.

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California State Science Fair
CEPCEB 2007 Plant Cell Biology First Place Award
The Center for Plant Cell Biology would like to acknowledge the 2007 recipient of the CEPCEB Plant Cell Biology First Place Award presented on May 22, 2007 at the California Science Fair.:
ALEX NOTHNAGEL
John W. North High School, Riverside
"Chemical Analysis of Glycosyl Composition of Cell Walls from Lower Land Plants "
This $1000 CEPCEB award is given to a student in the Senior Division. |
California State Science Fair
Plant Cell Biology Honorable Mention Award
The Center for Plant Cell Biology would like to acknowledge the 2007 recipient of the CEPCEB Plant Cell Biology Honorable Mention Award presented on May 22, 2007 at the California Science Fair:
SHADMAN CHOWDHURY
"An Innovative Method of Measuring Respiration in Germinating Seeds "
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CONGRATULATIONS to all the California State Science Fair Award Recipients!
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2007 Recipients of the CEPCEB Plant Cell Biology Awards at the RIMS Inland Science & Engineering Fair
The Center for Plant Cell Biology congratulates VASILIOS MORIKIS, the 2007 recipient of the CEPCEB Plant Cell Biology First Place Award presented on April 17, 2007 at the Inland Science and Engineering Fair in San Bernardino, California. The Fair is an annual competition of science projects designed, developed, and displayed by elementary and secondary students from schools in Riverside, Inyo, Mono and San Bernardino (RIMS) counties. CEPCEB annually acknowledges scientific achievement at this fair in the fields of cell and molecular biology, genomics, bioinformatics, or technology development by a student in grades 9-12. CEPCEB also congratulate SRAVYA KEREMANE, who received an Honorable Mention CEPCEB Award for his work.
The Center appreciates the contribution of members David Carter and A.L.N. Rao for participating as judges in this event.
2007 RIMS Inland Science and Engineering Fair CEPCEB Plant Cell Biology
FIRST PLACE AWARD |
2007 RIMS Inland Science and Engineering Fair CEPCEB Plant Cell Biology
HONORABLE MENTION AWARD |
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VASILIOS MORIKIS
Poly High School, Riverside, CA
"Dancing Helices in a Vacuum, a Computational Study of Peptide Molecular Dynamics"
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SRAVYA KEREMANE
North High School, Riverside, CA
"Biochemical Analysis of the Mechanism of Cold Tolerance in Citrus"
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CONGRATULATIONS TO THESE PROMISING YOUNG SCIENTISTS!
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CEPCEB Director Natasha Raikhel Recipient of the 2007 Fellow of ASPB Award
IIGB Director Natasha Raikhel has been selected as the 2007 recipient of the Fellow of ASPB Award. Established in 2007, the Fellow of ASPB Award is granted in recognition of distinguished and long-term contributions to plant biology and service to the Society of current members in areas that include research, education, mentoring, outreach, and professional and public service. Current members of ASPB who have contributed to the Society for at least 10 years are eligible for nomination. Recipients of the Fellow of ASPB honor are granted to no more than 0.2 of the current membership each year.
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CEPCEB IGERT Graduate Student Colleen Knoth Receives 8th Annual W.W. Thomson Award for Outstanding Research
At the annual Botany & Plant Sciences Research Retreat at the Botanic Gardens on May 11, 2007, CEPCEB ChemGen IGERT Graduate Student Colleen Knoth was awarded the 8th Annual W.W. Thomson Award for Outstanding Research. This cash award in the amount of $1200 is presented annually to a Ph.D. and/or Master's student in the Department of Botany and Plant Sciences who has demonstrated academic excellence and achievement in research. The award is named after William (Bill) W. Thomson, a retired faculty member from the Botany & Plant Sciences department who, upon retirement in 1999, established the W. W. Thomson Award fund. Professor Thomas developed a distinguished research record, focusing on the relationships between the structure of plant cells and their function. He is a world-renowned leader in the application of electron microscopy to the study of plant cell structure.
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CEPCEB Member Cynthia Larive Receives the 2007 J. Calvin Giddings Award for Excellence in Education
CEPCEB Member and Professor of Chemistry Cynthia Larive has received the 2007 J. Calvin Giddings Award in recognition of her excellence in teaching. Her contribution to the successful recruitment and mentoring of NSF REU and IGERT students alone attests to Dr. Larive's incredible contribution to the personal and professional development of students in the study of analytical chemistry. CEPCEB congratulates Cindy Larive on being selected by her professional peers for this well deserved award!
UCR Press Release (dated April 10, 2007)
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CEPCEB Member Xuemei Chen and IIGB Member Cheryl Hayashi Appointed 2006-07 University Scholars
Chancellor Córdova and Executive Vice Chancellor and Provost Ellen Wartella announced the appointment of the following University Scholars for the 2006-2007 academic year:
- Professor John Medearis: Department of Political Science
- Professor Xuemei Chen: Department of Botany & Plant Sciences
- Professor Cheryl Hayashi: Department of Biology
- Professor Gloria Gonzalez-Rivera: Department of Economics
The purpose of the University Scholar Award is to recognize early career tenured faculty of outstanding merit currently at UCR with title and research support for three years, thus providing an exciting opportunity to help rising stars achieve their potential. Please join us in congratulating and supporting the above awardees!
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Congratulations to 2007 Recipients of Outstanding CEPCEB Postdoctoral, Graduate Student and Undergraduate Student Awards at Fifth Annual CEPCEB Award Ceremony: February 9, 2007
The Center for Plant Cell Biology would like to congratulate the 2007 recipients of the following awards:
Outstanding CEPCEB
Postdoctoral Fellow |
Outstanding CEPCEB
Graduate Student |
Outstanding CEPCEB Undergraduate Student |
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TAKESHI FUKAO
Botany & Plant Sciences
(Mentor: J. Bailey-Serres)
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XIAO-HONG WANG
Plant Pathology
(Mentor: S.W. Ding) |
MONI BHATTACHARYA
Botany & Plant Sciences
(Mentor: H. Smith) |
The Fifth annual CEPCEB Special Award Ceremony was held February 9, 2007 from 2-4pm in the Science Library, Room 240. Awards were presented to individuals achieving research excellence in the fields of plant cell biology, genomics, bioinformatics or engineering. The CEPCEB Awards have a monetary value of $500 each, and awardees' names are posted on the website and added to a permanent plaque inscribed with the names of the CEPCEB lecturer and awardees each year. The Award Fund also sponsors our annual Special Seminar and Awards Ceremony where an invited leading scientist presents his or her work. In honor of one of the first supporters and members of CEPCEB, Dr. Noel Keen, this seminar is titled The Noel Keen Special Lecture. The late Dr. Keen was a founding CEPCEB member and an eminent scholar who brought considerable recognition to UCR. Recently, Dr. Keen's wife, Diana, decided to establish an endowment to help support our Special Lecture.
Dr. Bernard O. Palsson, Galetti Professor of Bioengineering and Adjunct Professor Medicine at the University of California, San Diego, was the 2007 Noel Keen Special Lecturer. Dr. Palsson is the author of over 220 peer reviewed scientific articles and the inventor of over 25
U.S. patents. He co-authored the text TISSUE ENGINEERING, Prentice Hall in 2004, and SYSTEMS BIOLOGY, Cambridge University Press in 2006. Dr. Palsson is the recipient of the Lindbergh Tissue Engineering award in 2001, was elected into the National Academy of Engineering in 2006, received the UCSD Chancellor's Associates award in Science and Technology in 2006, and was selected as the developer of one of the most influential technologies on Biotech over the past 10 years by Nature Biotechnology (March 2006). Professor Palsson's current research at UCSD focuses on 1) the reconstruction of genome-scale biochemical reaction networks, 2) the development of mathematical analysis procedures for genome-scale models, and 3) the experimental verification of genome-scale models with current emphasis on cellular metabolism and transcriptional regulation in E. coli and Yeast. Dr. Palsson continues our tradition of exceptional special lecturers with his seminar titled: "The Genetic Basis for Adaptation."
Congratulation to this year's deserving awardees.
Previous CEPCEB Awardees and Lecturers
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2007 Noel Keen Special Lecturer
Bernard O. Palsson |
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CEPCEB Student Michelle Brown Awarded Chancellor's Distinguished Fellowship
CEPCEB student Michelle Brown has been awarded the Chancellor's Distinguished Fellowship, an award selected by the Dean of the Graduate Division and limited to the very best
domestic PhD applicants with a 3.5 GPA and above and over a 1200 GRE score. Michelle was previously selected as a participant in NSF CEPCEB Research Experiences for Undergraduates program during the summers of 2004 and 2005, and has worked in the labs of CEPCEB members Kathy Borkovich, Patricia Springer and Natasha Raikhel. Our congratulations to Michelle, who has applied to the
Graduate Program in Genetics, Genomics and Bioinformatics (GGB).
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CEPCEB Member Xuemei Chen Recipient of 2006 Charles Albert Shull Award
CEPCEP Member and Associate Professor of Plant Cell and Molecular Biology, Xuemei Chen, was awarded the Charles Albert Shull Award by the American Society of Plant Biologists for her investigation of small RNA biogenesis and the role of miRNAs in plant development. Dr. Chen was one of the first to isolate miRNAs from plants, to analyze the role of miRNAs in plant development, and to define the major players in miRNA biogenesis.
The Charles Albert Shull Award of $2,000 is presented for outstanding research in plant biology by a scientist who is under 40 years of age or is less than ten years from receiving a Ph.D.
CEPCEB congratules Xuemei Chen on this prestigious award!
For more information, please visit the UCR Press Release (dated October 2, 2006).
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August 2006 Nature and The Plant Cell Papers by CEPCEB Member Julia Bailey-Serres Offers Hope of Submergence Tolerant Rice Lines for Poor Rice Farmers
Spearheaded by Dave Mackill, a rice breeder at the International Rice Research Institute (IRRI) and in collaboration with Pam Ronald at UC Davis and CEPCEB Member Julia Bailey-Serres, a paper was published in the August issue of Nature describing the cluster of genes controlling the ability of rice plants to withstand complete submergence due to flooding. The research, funded by the United States Department of Agriculture and the United States Agency for International Development (USAID) grants, reveals the discovery of a gene that can make a rice plant survive a long period of complete submergence, thereby offering the hope of submergence-tolerant rice lines for farmers in Southeast Asia and India who live in flood-prone areas. Postdocs Kenong Xu of IRRI, Takeshi Fukao in the Bailey-Serres' lab, and Abdel Ismail, a former UCR postdoc and current IRRI researcher, were also key contributors to this research.
A second paper published in The Plant Cell by the Bailey-Serres lab in collaboration with UC Davis researchers further describes the physiological mechanism of submergence tolerance, demonstrating how potentially any variety of rice could be made to survive short-term floods.
For more information, please visit the UCR Press Release (dated August 21, 2006) and UCR Press Release (dated August 9, 2006).
Xu K, Xu X, Fukao T, Canlas P, Maghirang-Rodriguez R, Heuer S, Ismail AM, Bailey-Serres J, Ronald PC, Mackill DJ (2006) Sub1A is an Ethylene-response-factor-like Gene that Confers Submergency Tolerance to Rice. Nature 442: 705-709. [Full Text PDF]
Fukao T, Xu K, Ronald PC, and Bailey-Serres J (2006) A Variable Cluster of Ethylene Response Factor-Like Genes Regulates Metabolic and Developmental Acclimation Responses to Submergency in Rice. The Plant Cell 18: 2021-2034. [Full Text PDF]
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High-throughput Genomics Project Published in June 2006 PNAS Issue by CEPCEB Member Katherine Borkovich
Researchers from Katherine Borkovich's lab in UCR's Plant Pathology department and from Jay Dunlap's lab at Darmouth Medical School have published a landmark high-throughput genomics paper in the Proceedings of the National Academy of Science, USA (PNAS) in the July 2006 issue. The citation, pdf file and abstract are below:
- Colot HV, Park G, Turner GE, Ringelberg C, Crew CM, Litvinkova L, Weiss RL, Borkovich KA and Dunlap JC (2006) A high-throughput gene knockout procedure for Neurospora reveals functions for multiple novel transcription factors. Proc Natl Acad Sci USA 103: 10352-10357.
Full Text PDF
Abstract: The low rate of homologous recombination exhibited by wild-type strains of filamentous fungi has hindered development of high-throughput gene knockout procedures for this group of organisms. In this study, we describe a method for rapidly creating knockout mutants in which we make use of yeast recombinational cloning, Neurospora mutant strains deficient in nonhomologous end-joining DNA repair, custom-written software tools, and robotics. To illustrate our approach, we have created strains bearing deletions of 103 Neurospora genes encoding transcription factors. Characterization of strains during growth and both asexual and sexual development revealed phenotypes for 43% of the deletion mutants, with more than half of these strains possessing multiple defects. Overall, the methodology, which achieves high-throughput gene disruption at an efficiency >90% in this filamentous fungus, promises to be applicable to other eukaryotic organisms that have a low frequency of homologous recombination.
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CEPCEB Member Thomas Eulgem Receives 2006 Chancellor's Award for Excellence in Undergraduate Research
CEPCEB Member Thomas Eulgem has been honored as the 2006 recipient of the Chancellor's Award for Excellence in Undergraduate Research for his consistently demonstrated dedication to quality education. As Assistant Director of the NSF-funded CEPCEB REU (Research Experience for Undergraduates) Program, currently in its fifth year, Dr. Eulgem was instrumental in recruiting ten underrepresented students from two- and four-year colleges to participate in this year's ten-week residential research program (June 19 - August 18, 2006). He has been the creative force behind the development of lab exercises that have become popular mainstays in student workshops, and has earned the respect and admiration of his students and colleagues for his enthusiastic approach to plant cell biology research and education.
Please join us in congratulating Dr. Eulgem on this special recognition.
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March 2006 Article in Science by CEPCEB Member Shou-wei Ding and Colleagues Show Fruit Flies Employ Same Defense Mechanism Against Viruses as Plants
CEPCEB member and Plant Pathologist Shou-wei Ding and colleagues have discovered that fruit flies use one of the same mechanisms as plants, RNA interference (RNAi), to defend themselves against viruses. In their article published in the March 24, 2006 issue of Science, Shou-wei Ding and colleagues reported that flies missing one of the three RNAi genes died more rapidly than normal flies when infected with two types of viruses. If, as suggested, humans also utilize the same mechanism, this study has important significance to future pharmaceutical strategies for fighting viruses.
For more information, please read "An Ointment in the Fly" in ScienceNOW.
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CEPCEB Member Stefano Lonardi Part of $5 Million USDA Research Consortium to Produce Better Barley
CEPCEB member and Computer Scientist Stefano Lonardi, along with Timothy Close from Botany & Plant Sciences, are part of a Coordinated Agricultural Project (CAP) of 30 scientists from 19 institutions awarded $5 million from the USDA to develop a better line of barley. As experts in single nucleotide polymorphisms (SNP) genotyping, UCR's barley CAP team hopes to continue developing algorithmic methods to efficiently identify genes responsible for certain traits. The goal of this national project is to provide breeders with genetic lines for producing barley with improved targeted traits, i.e., higher-yielding, better quality, disease-resistant, etc.
For more information, please visit UCR Press Release.
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CEPCEB Member Mihri Ozkan Receives Distinguished Engineering Educator Award
Mihri Ozkan, CEPCEB member and Assistant Professor in the Electrical Engineering Department, has received the
Distinguished Engineering Educator Award presented by the San Fernando Valley
Engineers' Council. The award honors individuals who demonstrate outstanding professional qualities with respect to engineering education and leadership, and who have significantly contributed to students' extracurricular engineering activities, and/or to scientific achievements.
Our congratulations go to Mihri for this well deserved recognition!
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CEPCEB
and UCR Researchers Discover Model Organism (C. elegans) for Studying Host-virus
Interactions (published in Nature, August 18, 2005)
 | UCR
researchers have made the landmark discovery that the worm, Caenorhabditis
elegans, is available as a genetic model for studying virus-host interactions.
Although C. elegans has been used for years as a model system for studying
many aspects of biology, it had not previously been considered useful as a model
for studying viral infections since no viruses were known to infect the worm.
However, UCR researchers have shown that the insect pathogen Flock house virus
replicates and elicits a strong antiviral defense in this nematode host. This
discovery advances researchers' understanding of virus-host interactions, and
may ultimately lead to significant progress in the treatment of human viral disease.
Findings were published in the August 18, 2005 issue of Nature as a collaborative
work among the following UCR researchers: CEPCEB member Shou-Wei-Ding;
Assistant Professor of Biology Morris Maduro; Microbiology graduate student Feng
Li; postdoctoral researchers in Ding's Lab, Rui Lu and Hongwei Li; and research
specialists Gina Broitman-Maduro and Wan-Xiang Li. Please read
the following press releases for further information: UCR
Press Release (August 17, 2005) Nature
Editor's Summary (August 18, 2005
| | Lu
R, Maduro M, Li F, Li HW, Broitman-Maduro G, Li WX and Ding SW (18 August 2005)
Animal virus replication and RNAi-mediated antiviral silencing in Caenorhabditis
elegans. Nature 436: 1040-1043. [Full
Text PDF] |
Back
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CEPCEB
Researchers Earn First NSF IGERT Grant for UCR ($2.9 Million) Under
principal investigator and CEPCEB member Julia
Bailey-Serres, the National Science Foundation has approved funding of $2.9
million for a five-year Integrative Graduate Education and Research Trainee (IGERT)
program that proposes to train 23 Ph.D. students versed in cell biology, chemistry,
computational sciences and engineering in advanced chemical genomics. The project,
titled "IGERT in Chemical Genomics: Forging Complementation at the Interface
of Chemistry, Engineering, Computational Sciences and Cell Biology," will
use chemical compounds to study the fundamental biology of cells through their
effects on genes and gene products, with the potential of addressing exciting
fundamental biological mechanisms with broad relevance from biotechnology to human
health. In additional to Bailey-Serres, co-principal investigators include the
following CEPCEB members: Natasha Raikhel,
Michael Pirrung, Tao
Jiang, and Jerome Schultz. |  |
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Congratulations
to Thomas Girke as Recipient of 2004-05 UCR Non-Senate Distinguished Research-Instruction
Award Our
congratulations are extended to Thomas Girke
as recipient of the 2004-05 Non Academic Senate Distinguished Research Instruction
Collaboration Award. Thomas was selected for this away due to his development
of a bioinformatics infrastructure for the Center of Plant Cell Biology and most
biology and biomedically-oriented departments at UC Riverside. With his outstanding
contribution and expertise, scientists at UC-Riverside are now performing science
on a different level. Please visit the Bioinformatics
web site for information about databases, bioinformatics tools and links to
various resources. Back
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ChemMine:
Compound Mining Database Developed by CEPCEB Member Thomas Girke Open to Public The
ChemMine Database developed by CEPCEB Member Thomas
Girke and containing over two million compounds can now be accessed by the
public. ChemMine is a compound mining database that facilitates drug and agrochemical
discovery and chemical genomics screens. Its goal is to facilitate chemical genomics
screens and to disseminate the generated knowledge. The database provides access
to a wide variety of bioactive, natural and screening compounds from public and
commercial providers. Their structures and functional annotations can be searched
by chemical properties, substructure matches, structural similarities and biological
activities. In addition to a comprehensive information retrieval system, ChemMine
is also a cheminformatics service for analyzing the structural and chemical properties
of lead compounds. This online service is available for compounds that are represented
in the database and those provided by the user. The current set of online analysis
tools includes structure-based clustering of compounds, generation of chemical
descriptors, and various viewing and reformatting functionalities. To efficiently
share the developed informatics resources with the community, the ChemMine project
has a strong commitment to open access and open source technology.
To
access the ChemMine Database, please visit: http://bioinfo.ucr.edu/projects/internal/PlantChemBase/search.php Back
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CEPCEB
Member Stefano Lonardi Awarded Five-Year NSF CAREER Grant Involving Bioinformatics
Research CEPCEB
Member Stefano Lonardi from
the Computer Science and Engineering Department was awarded a five-year NSF CAREER
grant for his project titled "Combinatorial Algorithms for Pattern Discovery
with Applications to Data Mining and Computational Biology." This award is
granted in support of the early career-development activities of those teacher-scholars
who are most likely to become the academic leaders of the 21st century, and, most
importantly, greatly advances bioinformatics efforts at UCR. Congratulations to
Stefano on this notable achievement!
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CEPCEB
Member Zhenbiao Yang's Paper in Cell (March 11, 2005) Explains Jigsaw-like
Pattern in Plant Cells Contributing to Leaf Strength
 | Fu
Y, Gu Y, Zheng Z, Wasteneys G, and Yang Z (2005) Arabidopsis Interdigitating
Cell Growth Requires Two Antagonistic Pathways with Opposing Action on Cell Morphogenesis.
Cell 120: 676-700. Summary: Coordinating growth
and communication between adjacent cells is a critical yet poorly understood aspect
of tissue development and organ morphogenesis. We report a Rho GTPase signaling
network underlying the jigsaw puzzle appearance of Arabidopsis leaf pavement cells,
in which localized outgrowth in one cell is coordinated with localized inhibition
of outgrowth of the adjacent cell to form interdigitating lobes and indentations.
Locally activated ROP2, a Rho-related GTPase from plants, activates RIC4 to promote
the assembly of cortical actin microfilaments required for localized outgrowth.
Meanwhile, ROP2 inactivates another target RIC1, whose activity promotes well-ordered
cortical microtubules. RIC1-dependent microtubule organization not only locally
inhibits outgrowth but in turn suppresses ROP2 activation in the indentation zones.
Thus, outgrowth-promoting ROP2 and outgrowth-inhibiting RIC1 pathways antagonize
each other. We propose that the counteractivity of these two pathways demarcates
outgrowing and indenting cortical domains, coordinating a process that gives rise
to interdigitations between adjacent pavement cells. Figure:
A Model for ROP GTPase
Control of Pavement Cell Morphogenesis Interdigitating
growth in Arabidopsis leaf pavement cells is controlled by a ROP GTPase signaling
network containing two counteracting pathways with opposing actions on localized
cell expansion: the ROP-RIC4 pathway promotes lobe outgrowth via a fine cortical
MF network, while the RIC1 pathway suppresses outgrowth via well-organized cortical
MTs. We postulate that, during the initiation of lobes and indentations, these
two pathways are locally activated and spatially separated, but they may subsequently
counteract each other as a result of their respective self-amplification along
the cell cortex. The countersignaling establishes borders that separate outgrowth-promoting
from outgrowth-suppressing domains of the cell cortex. Solid arrows indicate steps
supported by direct experimental evidence, and dotted arrows show hypothetical
steps with some direct evidence. |
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CEPCEB
Member Howard Judelson Recipient of the 2004 Ruth Allen Award CEPCEB
Member Howard Judelson was
recently awarded the 2004 Ruth Allen Award from the American Phytopathological
Society. The Ruth Allen Award honors individuals who have made an outstanding,
innovative research contribution that has changed, or has the potential to change,
the direction of research in any field of plant pathology. Our congratulations
to Howard Judelson on this recognition of his contribution to the field of plant
pathology! Back to Top 
CEPCEB
Member Mihri Ozkan Recipient of Visionary Science Award by ISBBN CEPCEB
Member Mihri Ozkan,from the
Electrical Engineering and Chemical/Environmental Engineering departments, has
been awarded the prestigious Visionary Science Award from the International Society
for Bio-MEMS and Biomedical Nanotechnology (ISBBN) for her novel work in the area
of Brain-on-a chip. The award was presented in Washington, DC. Our congratulations
to Mihri Ozkan for this prestigious award! Back
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Natasha
Raikhel Recipient of 2004 Stephen Hales Prize Natasha
Raikhel, Director of the Center for Plant Cell Biology, was awarded the 2004
Stephen Hales Prize. This annual award honors the Reverend Stephen Hales for his
pioneering work in plant biology published in his 1727 book Vegetable Staticks.
It is a monetary award established in 1927 for a scientist, whether or not a member
of the Society, who has served the science of plant biology in some noteworthy
manner.
Please join us in congratulating Natasha Raikhel for this prestigious
award! Back to Top 
CEPCEB
Member Katherine Borkovich First Author in MMBR Article that Analyzes over 1,100
genes of fungus Neurospora crassa (March 2004) CEPCEB
Member Katherine Borkovich
is first author on a review article (108 pages) titled "Lessons from the
Genomic Sequence of Neurospora crassa: Tracing the Path from Genomic Blueprint
to Multicellular Organism," published in the March 2004 issue of Microbiology
and Molecular Biology Reviews (MMBR)*. This review provides an in-depth analysis
of over 1,100 genes in the Neurospora crassa genome sequence. Katherine
A. Borkovich, Lisa A. Alex, Oded Yarden, Michael Freitag, Gloria E. Turner, Nick
D. Read, Stephan Seiler, Deborah Bell-Pedersen, John Paietta, Nora Plesofsky,
Michael Plamann, Marta Goodrich-Tanrikulu, Ulrich Schulte, Gertrud Mannhaupt,
Frank E. Nargang, Alan Radford, Claude Selitrennikoff, James E. Galagan, Jay C.
Dunlap, Jennifer J. Loros, David Catcheside, Hirokazu Inoue, Rodolfo Aramayo,
Michael Polymenis, Eric U. Selker, Matthew S. Sachs, George A. Marzluf, Ian Paulsen,
Rowland Davis, Daniel J. Ebbole, Alex Zelter, Eric R. Kalkman, Rebecca O'Rourke,
Frederick Bowring, Jane Yeadon, Chizu Ishii, Keiichiro Suzuki, Wataru Sakai, and
Robert Pratt (2004) Lessons from the Genome Sequence of Neurospora crassa:
Tracing the Path from Genomic Blueprint to Multicellular Organism. Microbiol.
Mol. Biol. Rev. 68: 1-108.
Abstract We present an analysis
of over 1,100 of the 10,000 predicted proteins encoded by the genome sequence
of the filamentous fungus Neurospora crassa. Seven major areas of Neurospora genomics
and biology are covered. First, the basic features of the genome, including the
automated assembly, gene calls, and global gene analyses are summarized. The second
section covers components of the centromere and kinetochore complexes, chromatin
assembly and modification, and transcription and translation initiation factors.
The third area discusses genome defense mechanisms, including repeat induced point
mutation, quelling and meiotic silencing, and DNA repair and recombination. In
the fourth section, topics relevant to metabolism and transport include extracellular
digestion; membrane transporters; aspects of carbon, sulfur, nitrogen, and lipid
metabolism; the mitochondrion and energy metabolism; the proteasome; and protein
glycosylation, secretion, and endocytosis. Environmental sensing is the focus
of the fifth section with a treatment of two-component systems; GTP-binding proteins;
mitogen-activated protein, p21-activated, and germinal center kinases; calcium
signaling; protein phosphatases; photobiology; circadian rhythms; and heat shock
and stress responses. The sixth area of analysis is growth and development; it
encompasses cell wall synthesis, proteins important for hyphal polarity, cytoskeletal
components, the cyclin/cyclin-dependent kinase machinery, macroconidiation, meiosis,
and the sexual cycle. The seventh section covers topics relevant to animal and
plant pathogenesis and human disease. The results demonstrate that a large proportion
of Neurospora genes do not have homologues in the yeasts Saccharomyces cerevisiae
and Schizosaccharomyces pombe. The group of unshared genes includes potential
new targets for antifungals as well as loci implicated in human and plant physiology
and disease. *A journal's impact factor is is a measure of the frequency
with which the "average article" in a journal has been cited in a particular
year or period and is one of the quantitative tools for ranking, evaluating, categorizing,
and comparing journals. MMBR's impact factor is ranked #1 out of 82 journals in
the Microbiology category. Back to Top 
CEPCEB
Member Elizabeth Lord's PNAS Paper (December
2003) Identifies Plant
Reproduction Protein  | CEPCEB
Member Elizabeth Lord's lab
has identified a protein that helps guide sperm to the egg in flowering lily plants,
and their results are to be published in a paper titled Chemocyanin, a Small,
Basic Protein from the Lily Stigma, Induces Pollen Tube Chemotropism in
the Proceedings of the National
Academy of Sciences. The importance of understanding how plants
reproduce is enormous for the future manipulation of crop and nursery plants.
There is a huge flower industry in California and little is known about how seed
set occurs in flowering plants. Elizabeth's Lord's lab does research on the mechanisms
of seed production and have attempted to discover how pollen tubes, which carry
sperm cells, are guided to the egg cell in the ovary. Their discovery of a protein
from the pistil which acts to guide pollen tubes to the egg cell is a first for
flowering plants. Insemination begins when pollen grains land on the stigma,
the tip of the female reproductive organ. There the grains germinate and form
a pollen tube that carries sperm cells to the ovary, where the egg-containing
ovules reside. Botanists have long known that the female organs play a role in
guiding pollen tubes to the ovules, but the molecular mechanism was unknown. Elizabeth
Lord and colleagues used biochemical methods to identify chemocyanin as the protein
that guides pollen tube growth on the large lily stigma. Chemocyanin belongs to
a family of proteins called plantacyanins, which have unknown functions, but are
found in the cell walls of many plant species. Lord's team found that chemocyanin's
effect on lily pollen tube guidance is species-specific because it does not attract
tobacco pollen tubes. Chemocyanin was more effective when another cell wall protein
called SCA was present. Identification of these two and other similar peptides
may unlock the network of signals involved in plant reproduction. |
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CEPCEB Small Research
Grants Awarded for Microscopy and Imaging The Center for
Plant Cell Biology awarded two seed grants of $2,000 to the following recipients
for projects using the Microscopy and Imaging resources in the core facility: | Name: | Juan
Dong, Graduate Student | Christian
Lytle, Associate Professor | | Department: | Botany
& Plant Sciences | Biomedical
Sciences | | Project: | Localization
of chemocyanin in the lily pistil and on in vitro grown pollen tubes | The
kinetics of intraluminal acidification of gastric glands |
These
grants will be administered as a 12-month line of credit to be spent at the CEPCEB
core facility on billable equipment. The following equipment is available: - Leica
SP2 UV confocal microscope with 9 laser lines and spectral detection
- Meridian
InSight ocular viewing confocal with Ar and Kr lasers and Hamamatsu C4880 camera
- Atto
Pathway HT fully automated confocal imaging system, now with montage capability
- Leica
MZIII fluorescence stereo scopes with Combi turret, SPOT b/w and JVC color cameras
- MCID
Elite image analysis system with motorized Zeiss Axiovert microscope
- Photonic
Microsystems pulsed laser on a motorized laser ablation microscope platform
- Leica
Ultracut T with EM FCS cryo unit for preparing TEM samples (Expert users only)
- Sorvall
MT 6000 ultramicrotome for preparing TEM samples
- EMS 5000 oscillating
tissue slicer for live tissue sectioning under water
- Hacker 5030 microtome
for routine plastic and wax histological sectioning
- Microm HM500 OMV motorized
cryostat with "vacutome" feature for cutting flat cryosections
- BioRad
PDS1000/He Biolistic gene gun with Hepta adaptor for wide area coverage
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Paper
Published in the Proceedings of the
National Academy of Sciences (PNAS) June
10, 2003 Issue by
Raikhel Lab Research
funded by the National Science Foundation to show that plants use unique mechanisms
to process and degrade proteins was recently published in the June 10, 2003 issue
of the Proceedings of the National Academy of Sciences (PNAS). Authors of this
manuscript are Natasha Raikhel
and the following members of her research laboratory: Enrique Rojo, Jan Zouhar,
Clay Carter and Valentina Kovaleva. 91. Rojo E, Zouhar J,
Carter C, Kovaleva V, Raikhel NV (2003) A Unique Mechanism for Protein Processing
and Degradation in Arabidopsis Thaliana. Proc. Natl. Acad. Sci. USA
100: 7389-7394. Abstract: Precursor protease vesicles are plant-specific
compartments containing precursors of enzymes that are thought to participate
in the degradation of cellular components in organs undergoing senescence. We
report in vivo evidence that the precursor protease vesicle-localized vacuolar
processing enzyme-γ (VPEγ) is critical for maturation of the plant vacuolar
protease AtCPY. We also provide biochemical and functional evidence that VPEγ
is involved in degradation of the vacuolar invertase AtFruct4 in aging tissues.
Moreover, a proteomics-based approach identified various proteins found in the
vacuoles of aging vpeγ mutants but not in WT plants, suggesting a unique
role of VPEγ in protein processing and degradation in Arabidopsis. Please
see UCR
Press Release (June 5, 2003) Full
Text PDF Back to Top 
June
2003 Special Issue of Plant Physiology Has Significant CEPCEB Contributions
 | The
June 2003 issue of Plant
Physiology
contains significant contributions made by CEPCEB faculty and staff. Subtitled
"Arabidopsis Special Issue: Plant Systems Biology," the issue is one
of the first publications devoted to systems-based research - the new multidisciplinary,
computational approach for addressing biological issues and the wave of the future
in plant biology. In addition to this innovative emphasis, the issue also bears
the following UCR contributions: 1) The Center for Plant Cell Biology (CEPCEB)
Director Natasha Raikhel and CEPCEB member Zhenbiao Yang from Botany & Plant
Sciences organized the 22nd Symposium in Plant Biology held on January 15-18,
2003 at the Riverside Convention Center. A report highlighting this international
meeting, entitled "Frontiers of Plant Cell Biology: Signals and Pathways,
System-Based Approaches 22nd Symposium in Plant Biology (University of California-Riverside)"
is located on pages 428-435. Full
Text PDF 2) The "Editor's Choice" article is a summary report
written with the assistance of participants at a DOE workshop held at the Mission
Inn on January 19, 2003, the day after the 22nd Symposium in Plant Biology. The
report entitled "Achieving the in Silico Plant. Systems Biology and the Future
of Plant Biological Research" can be found on pages 404-409. Full
Text PDF 3) The first article of the issue, listed under "Perspectives
on Systems Biology," is a collaborative effort among CEPCEB members from
Botany & Plant Sciences (Thomas Girke, David Carter and Natasha Raikhel) and
Electrical Engineering (Mihri Ozkan). This lead article, titled "Towards
a Modeling Infrastructure for Studying Plant Cells" is located on pages 410-414.
Full Text PDF 4)
The cover of the issue was designed and developed by Jocelyn Brimo, a CEPCEB staff
member and assistant to Natasha Raikhel. The editorial for the issue was co-authored
by Raikhel. Full Text
PDF | Back to Top

CEPCEB
Member Katherine Borkovich's Paper Published in Nature Involving Sequencing
of the Neurospora Genome (April 24, 2003)CEPCEB
Member Katherine Borkovich
was the third author and first non-sequencing center author on a paper published
in the April 24, 2003 issue of Nature titled "The genome sequence
of the filmentous fungus Neorospora crassa."
Galagan JE, Calvo SE, Borkovich KA, Selker EU, Read ND, Jaffe D, FitzHugh W, Ma,
LJ, Smirnov S, Purcell S, Rehman B, Elkins T, Engels R, Wang S, Nielsen CB, Butler
J, Endrizzi M, Qui D, Ianakiev P, Bell-Pedersen D, Nelson MA, Werner-Washburne
M, Selitrennikoff CP, Kinsey JA, Braun EL, Zelter A, Schulte U, Kothe GO, Jeff
G, Mewes W, Staben C, Marcotte E, Greenberg D, Roy A, Foley K, naylor J, Stange-Thomann
N, Barrett R, Gnerre S, Kamal M, Kamvysselis M, Mauceli E, Bielke C, Rudd S, Frishman
D, Krystofova S, Rasmussen C, Metzenberg RL, Perkins DD, Kroken S, Cogoni C, Macino
G, Catcheside D, Li W, Pratt RJ, Osmani SA, DeSouza CPC, Glass L, Orbach MJ, Berglund
JA, Voelker R, Yarden O, Plamann M, Seiler S, Dunlap J, Radford A, Aramayo R,
Natvig DO, Alex LA, Mannhaupt G, Ebbole DJ, Freitag M, Paulsen I, Sachs MS, Lander
ES, Nusbaum C, Birren B. (2003) The genome sequence of the filamentous fungus
Neorospora crassa. Nature: 422: 859-868. Abstract:
Neorospora crassa is a central organism in the history of twentieth-century
genetics, biochemistry and molecular biology. Here, we report a high-quality draft
sequence of the N. crassa genome. The approximately 40-megabase genome
encodes about 10,000 protein-coding genes more than twice as many as in
the fission yeast Schizosaccharomyces pombe and only about 25% fewer than
in the fruitfly Drosophila melanogaster. Analysis of the gene set yields
insights into unexpected aspects of Neurospora biology including the identification
of genes potentially associated with red light photobiology, genes implicated
in secondary metabolism, and important differences in Ca2+ signalling as compared
with plants and animals. Neurospora possesses the widest array of genome defence
mechanisms known for any eukaryotic organism, including a process unique to fungi
called repeat-induced point mutation (RIP). Genome analysis suggests that RIP
has had a profound impact on genome evolution, greatly slowing the creation of
new genes through genomic duplication and resulting in a genome with an unusually
low proportion of closely related genes. Full
Text PDF News Feature Article titled
"Revelations from a bread mould" by Jonathan Arnold and Nelson Hilton
(PDF) The Center
for Plant Cell Biology congratulates Katherine
Borkovich on this landmark paper! Back
to Top 
CEPCEB
Paper (Zhenbiao Yang, Ying Fu) Selected as Fast Breaking by ISI Essential Science
Indicators ISI Essential Science
Indicators list the top 1% highly-cited papers in 22 broad field of science
each year from 1992-2002. The lists are updated every two months, and for the
fifth to sixth bimonthly period of 2002, an article by CEPCEB member Zhenbiao
Yang and Dr. Ying Fu was selected as one of 12 Fast Breaking Papers with the highest
percentage increase in citations, representing the field of Plant and Animal Science.
These papers are noted (http://www.esi-topics.com/fbp/fbp-april2003.html)
because they "represent very recent scientific contributions that are just
beginning to attract the attention of the scientific community." The paper
is titled "The ROP2 GTPase controls the formation of cortical fine F-actin
and the early phase of directional cell expansion during Arabidopsis organogenesis."
Please visit: http://www.esi-topics.com/fbp/fbp-april2003.html. Our
congratulations to Drs. Zhenbiao
Yang and Ying Fu for this remarkable achievement! Back
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